Publications

• Turner ME, Nakamura Y, Tanaka T, Blaser MC, Kasai T, Lupieri A, Itoh S, Ge R, Perez KA, Itagawa R, Weiss L, Okui T, Sasaki Y, Pradhan AD, Libby P, Ridker PM, Singh SA, Aikawa M, Aikawa E

  Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease. bioRxiv. 2025;:ePub - PMID: 41446100 - PMCID: PMC12724596 - DOI: 10.64898/2025.12.17.694919

• Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Colorado Center for Personalized Medicine, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, DBDS Genomic Consortium, Sveinbjornsson G, Gudbjartsson DF, Abner E, Estonian Biobank Research Team, Lee J, Ganna A, Nowak-Göttl U, Finer S, Genes & Health Research Team, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreβen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O'Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G

  Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. Nat Genet. 2025;58(1):57-66 - PMID: 41419686 - PMCID: PMC12807872 - DOI: 10.1038/s41588-025-02417-6

• Yao J, Farrar CT, Aikawa E, Sosnovik DE, Moon BF, Kulkarni A, Ackerman JL

  Ex vivo phosphorus-31 solid state magnetic resonance spectroscopy identifies compositional differences between bone mineral and calcified vascular tissues. Front Cardiovasc Med. 2025;12:1689116 - PMID: 41383646 - PMCID: PMC12689968 - DOI: 10.3389/fcvm.2025.1689116

• Aikawa M, Sonawane AR, Chelvanambi S, Asano T, Halu A, Matamalas JT, Singh SA, Uchida S, Aikawa E, Arenas A, Balligand JL, Giannarelli C, MacRae CA, Morgan NV, Oury C, Stahel HT, Loscalzo J

  Precision cardiovascular medicine: shifting the innovation paradigm. Front Sci. 2025;3:ePub - PMID: 41378166 - PMCID: PMC12687475 - DOI: 10.3389/fsci.2025.1474469

• Mutarelli A, Pantaleao AN, Melo PHC, Nogueira W, Nogueira A, Felix N, Generoso G, Cardoso R, Lupieri A, Aikawa E, Levine RA, Nunes MCP

  Global prevalence and sex differences in rheumatic heart disease: a systematic review and updated meta-analysis. Front Cardiovasc Med. 2025;12:1615158 - PMID: 41282342 - PMCID: PMC12631635 - DOI: 10.3389/fcvm.2025.1615158

• Yao J, Farrar CT, Aikawa E, Sosnovik DE, Moon BF, Kulkarni A, Ackerman JL

  Ex Vivo Phosphorus-31 Solid State Magnetic Resonance Spectroscopy Identifies Compositional Differences Between Bone Mineral and Calcified Vascular Tissues. medRxiv. 2025;:ePub - PMID: 41256110 - PMCID: PMC12622083 - DOI: 10.1101/2025.09.27.25336805

• Hall IF, Aikawa E, Sluimer J, Baker AH, Kovacic JC

  Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives. Eur Heart J. 2025;:ePub - PMID: 41128016 - DOI: 10.1093/eurheartj/ehaf670

• Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N

  Author Correction: Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold. Commun Biol. 2025;8(1):1459 - PMID: 41083580 - PMCID: PMC12518614 - DOI: 10.1038/s42003-025-08927-7

• Jha PK, Chelvanambi S, Nakamura Y, Itto LYU, Vijay A, Lupieri A, Barbeiro MC, Le TD, Nascimento CB, Kasai T, Whelan MC, Hosokawa D, Becker-Greene D, Singh SA, Aikawa E, Uchida S, Aikawa M

  A systems approach to target discovery identifies the role of lncRNA-SPANXA2-OT1 in macrophage chemotaxis. JCI Insight. 2025;10(21):ePub - PMID: 41066194 - PMCID: PMC12643516 - DOI: 10.1172/jci.insight.191274

• Song N, Yu J, Ji E, Yoon J, Choi KH, Yu JE, Kim B, Kim J, Kim M, Lee S, Kim K, Aikawa E

  Characterization of Proteome Features in Patients With Aortic Stenosis Using Data-Independent Acquisition-Based Proteomic Analysis. Korean Circ J. 2025;56(1):80-96 - PMID: 41044724 - PMCID: PMC12834629 - DOI: 10.4070/kcj.2025.0137

• Santinelli-Pestana DV, Delwarde C, Kasai T, Kuraoka S, Nakamura Y, Okada T, Decano JL, Chelvanambi S, Ge R, Mlynarchik AK, Perez K, Campedelli A, Sonawane AR, Aikawa E, Singh SA, Aikawa M

  ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2025;45(11):2137-2139 - PMID: 40905119 - PMCID: PMC12542996 - DOI: 10.1161/ATVBAHA.125.322497

• Goody PR, Christmann D, Goody D, Hildebrand S, Billig H, Nehl D, Chennupati R, Gladka M, Wilhelm-Jüngling K, Uchida S, Iris-Bibli S, Moore JB, Hamdani N, Paneni F, Pullamsetti SS, Zimmer S, Jansen F, Bakhtiary F, Aikawa E, Pfeifer A, Nickenig G, Hosen MR

  Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk. Basic Res Cardiol. 2025;120(5):991-1010 - PMID: 40847220 - PMCID: PMC12518376 - DOI: 10.1007/s00395-025-01133-w

• Clift CL, Blaser MC, Bartoli-Leonard F, Schlotter F, Higashi H, Kuraoka S, Kasai T, Turner ME, Pham T, Perez KA, Robson SC, Body SC, Muehlschlegel JD, Aikawa M, Singh SA, Aikawa E

  Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis. Arterioscler Thromb Vasc Biol. 2025;45(10):1928-1934 - PMID: 40808650 - DOI: 10.1161/ATVBAHA.125.322560

• Jha PK, Aikawa M, Aikawa E

  Indoxyl sulfate: fuelling cardiovascular inflammation and calcification. Cardiovasc Res. 2025;121(11):1642-1644 - PMID: 40795292 - PMCID: PMC12477674 - DOI: 10.1093/cvr/cvaf134

• Clift CL, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh SA, Levine RA, Pernot M, Aikawa E

  Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture. Ultrasound Med Biol. 2025;51(11):1936-1944 - PMID: 40796501 - DOI: 10.1016/j.ultrasmedbio.2025.06.026

• Delwarde C, Matamalas JT, Chelvanambi S, Kasai T, Shlayen G, Santinelli-Pestana DV, Zamani M, Aikawa E, Aikawa M, Singh SA

  Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model. bioRxiv. 2025;:ePub - PMID: 40766711 - PMCID: PMC12324543 - DOI: 10.1101/2025.08.01.667173

• Cahalane RME, Meuris B, Matamalas JT, Blaser MC, Billaud M, Kasai T, Hendrickx A, Goeminne LJE, Muehlschlegel J, Rega F, Aikawa M, McNamara L, Singh SA, Clift CL, Aikawa E

  Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials. bioRxiv. 2025;:ePub - PMID: 40667106 - PMCID: PMC12262681 - DOI: 10.1101/2025.06.24.661315

• Lupieri A, Becker-Greene D, Le TD, Roschel MM, Jha PK, Sonawane AR, Mullick A, Tsimikas S, Kuraoka S, Singh SA, Aikawa M, Aikawa E

  Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner. Arterioscler Thromb Vasc Biol. 2025;45(8):1398-1415 - PMID: 40501380 - PMCID: PMC12503371 - DOI: 10.1161/ATVBAHA.124.321999

• Higuita ML, Ajenu EO, Bolger-Chen M, Olverson G, Akbari Ghavimi SA, Lee SY, Kasai T, Michaud W, Chijioke C, Ruidas B, Pitti A, Minie N, Catricala J, Vincent D, Li S, D'Alessandro D, Aikawa E, Singh SA, Billaud M, Osho AA, Tessier SN, Rabi SA

  Alternative preservation strategies of DCD hearts: Effect of cold ischemia time before normothermic machine perfusion. medRxiv. 2025;:ePub - PMID: 40502597 - PMCID: PMC12154999 - DOI: 10.1101/2025.06.04.25329001

• Lupieri A, Aikawa E

  Decoding calcific aortic valve disease: is liver X receptor the key to lipid metabolism?. Cardiovasc Res. 2025;121(6):844-846 - PMID: 40389228 - DOI: 10.1093/cvr/cvaf080

• Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RME, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman MA, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL

  Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks. Arterioscler Thromb Vasc Biol. 2025;45(7):1277-1305 - PMID: 40438929 - PMCID: PMC12188822 - DOI: 10.1161/ATVBAHA.124.322324