Publications

• Turner ME, Nakamura Y, Tanaka T, Blaser MC, Kasai T, Lupieri A, Itoh S, Ge R, Perez KA, Itagawa R, Weiss L, Okui T, Sasaki Y, Pradhan AD, Libby P, Ridker PM, Singh SA, Aikawa M, Aikawa E

  Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease. bioRxiv. 2025;:ePub - PMID: 41446100 - PMCID: PMC12724596 - DOI: 10.64898/2025.12.17.694919

• Aikawa M, Sonawane AR, Chelvanambi S, Asano T, Halu A, Matamalas JT, Singh SA, Uchida S, Aikawa E, Arenas A, Balligand JL, Giannarelli C, MacRae CA, Morgan NV, Oury C, Stahel HT, Loscalzo J

  Precision cardiovascular medicine: shifting the innovation paradigm. Front Sci. 2025;3:ePub - PMID: 41378166 - PMCID: PMC12687475 - DOI: 10.3389/fsci.2025.1474469

• Jha PK, Chelvanambi S, Nakamura Y, Itto LYU, Vijay A, Lupieri A, Barbeiro MC, Le TD, Nascimento CB, Kasai T, Whelan MC, Hosokawa D, Becker-Greene D, Singh SA, Aikawa E, Uchida S, Aikawa M

  A systems approach to target discovery identifies the role of lncRNA-SPANXA2-OT1 in macrophage chemotaxis. JCI Insight. 2025;10(21):ePub - PMID: 41066194 - PMCID: PMC12643516 - DOI: 10.1172/jci.insight.191274

• Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Bejan DS, Chen Y, Suder EL, Schwarting N, Aikawa M, Muhlberger E, Hume AJ, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Fehr AR

  PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses. mBio. 2025;16(10):e0229925 - PMID: 40937852 - PMCID: PMC12505956 - DOI: 10.1128/mbio.02299-25

• Santinelli-Pestana DV, Delwarde C, Kasai T, Kuraoka S, Nakamura Y, Okada T, Decano JL, Chelvanambi S, Ge R, Mlynarchik AK, Perez K, Campedelli A, Sonawane AR, Aikawa E, Singh SA, Aikawa M

  ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2025;45(11):2137-2139 - PMID: 40905119 - PMCID: PMC12542996 - DOI: 10.1161/ATVBAHA.125.322497

• Clift CL, Blaser MC, Bartoli-Leonard F, Schlotter F, Higashi H, Kuraoka S, Kasai T, Turner ME, Pham T, Perez KA, Robson SC, Body SC, Muehlschlegel JD, Aikawa M, Singh SA, Aikawa E

  Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis. Arterioscler Thromb Vasc Biol. 2025;45(10):1928-1934 - PMID: 40808650 - DOI: 10.1161/ATVBAHA.125.322560

• Sun J, Aikawa M, Ashktorab H, Beckmann ND, Enger ML, Espinosa JM, Gai X, Horne BD, Keim P, Lasky-Su J, Letts R, Maier CL, Mandal M, Nichols L, Roan NR, Russell MW, Rutter J, Saade GR, Sharma K, Shiau S, Thibodeau SN, Yang S, Miele L, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

  A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions. Front Syst Biol. 2025;4:1422384 - PMID: 40809128 - PMCID: PMC12342036 - DOI: 10.3389/fsysb.2024.1422384

• Jha PK, Aikawa M, Aikawa E

  Indoxyl sulfate: fuelling cardiovascular inflammation and calcification. Cardiovasc Res. 2025;121(11):1642-1644 - PMID: 40795292 - PMCID: PMC12477674 - DOI: 10.1093/cvr/cvaf134

• Clift CL, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh SA, Levine RA, Pernot M, Aikawa E

  Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture. Ultrasound Med Biol. 2025;51(11):1936-1944 - PMID: 40796501 - DOI: 10.1016/j.ultrasmedbio.2025.06.026

• Delwarde C, Matamalas JT, Chelvanambi S, Kasai T, Shlayen G, Santinelli-Pestana DV, Zamani M, Aikawa E, Aikawa M, Singh SA

  Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model. bioRxiv. 2025;:ePub - PMID: 40766711 - PMCID: PMC12324543 - DOI: 10.1101/2025.08.01.667173

• Boeck M, Yagi H, Lundgren P, Pivodic A, Nilsson AK, Zeng Y, Chen CT, Kasai T, Lee D, Nian S, Hirst V, Neilsen K, Wang C, Lee J, Yu M, McCutcheon A, Singh SA, Aikawa M, Bazinet RP, Fu Z, Hellström A, Smith LE

  Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice. Pharmacol Res. 2025;219:107877 - PMID: 40706777 - PMCID: PMC12445345 - DOI: 10.1016/j.phrs.2025.107877

• Cahalane RME, Meuris B, Matamalas JT, Blaser MC, Billaud M, Kasai T, Hendrickx A, Goeminne LJE, Muehlschlegel J, Rega F, Aikawa M, McNamara L, Singh SA, Clift CL, Aikawa E

  Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials. bioRxiv. 2025;:ePub - PMID: 40667106 - PMCID: PMC12262681 - DOI: 10.1101/2025.06.24.661315

• Lupieri A, Becker-Greene D, Le TD, Roschel MM, Jha PK, Sonawane AR, Mullick A, Tsimikas S, Kuraoka S, Singh SA, Aikawa M, Aikawa E

  Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner. Arterioscler Thromb Vasc Biol. 2025;45(8):1398-1415 - PMID: 40501380 - PMCID: PMC12503371 - DOI: 10.1161/ATVBAHA.124.321999